New research indicates that patients who discontinue popular GLP-1 drugs like Mounjaro or Wegovy may regain shed pounds far faster than those who halt conventional diet and exercise programs.
Findings released in a major medical journal shows that while obese individuals can lose substantial amounts of their body weight while on the medication, the mass is regained at an average rate of 0.8 kg per month upon discontinuation.
"People buying such medications must be aware of the danger of quick rebound weight gain when the treatment is stopped," cautioned lead investigator Dr. Susan Jebb.
Such speed of recovery means a return to pre-treatment weight in about 18 months.
Weighing Therapies
The study, which looked at dozens of studies involving thousands of patients, compared the effects of these new drugs with older methods.
The team point out that people who shed pounds through lifestyle changes alone typically experience a more gradual weight regain—around 0.1 kg a month—once they finish.
Understanding the Fast Regain
Doctors believe the mode of action of the jabs accounts for the amplified weight return.
These medications mimic a body's own chemical called GLP-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the body to produce less of its endogenous GLP-1, and may also diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this medication means appetite is uncontrolled, making binge eating much more probable."
A Chronic Condition?
Health authorities recommend the jabs for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Professionals say that, considering the significant potential of weight regain, the therapy should be considered ongoing.
This perspective is reinforced by pharmaceutical companies, who note that the results "highlight the chronic character of excess weight," similar to managing diseases like high blood pressure.
Patient Accounts
Individuals who have discontinued the jabs explain a intense return of appetite.
"It was like something flipping and you become extremely hungry," said one woman.
This difficulty is exacerbated if individuals have not adopted permanent lifestyle or habit changes during therapy.
Widespread Interest
Figures suggest that a significant number of adults in the UK have used weight-loss jabs in the past year, with desire continuing to grow.
- Use is higher among women compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion access the drugs through private prescriptions rather than the NHS.
Finally, clinicians stress that while the jabs are powerful agents for shedding pounds, they are not a magic cure and maintained weight loss hinges on combined behavioural support.
